Catalog no.
B1198-25
B1198-25
25 mg
632 EUR
No
Yes
N/A
N/A
cell
-20°C
475.42
gel pack
36 months
311795-38-7
Biochemicals
≥98% by HPLC
DMSO (>5 mg/ml)
Off-white solid
C₂₇H₂₇BrN₂O
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
Glutaminase C-IN-1 (968) a cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC₅₀ = ~2.5 µM), which is commonly found in cancer cells. Glutaminase C-IN-1 (968) blocks transformation induced by Rho GTPases and inhibits the proliferation of non-invasive epithelial (T-47D and MDA-MB-361) and invasive mesenchymal (MDA-MB-231 and Hs578T) cancer cells, without affecting normal cells. Glutaminase C-IN-1 (968) induces apoptosis and alters both histone methylation and gene expression in cancer cells.