≥98% by HPLC
DMSO (>5 mg/ml)
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
Glutaminase C-IN-1 (968) a cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC₅₀ = ~2.5 µM), which is commonly found in cancer cells. Glutaminase C-IN-1 (968) blocks transformation induced by Rho GTPases and inhibits the proliferation of non-invasive epithelial (T-47D and MDA-MB-361) and invasive mesenchymal (MDA-MB-231 and Hs578T) cancer cells, without affecting normal cells. Glutaminase C-IN-1 (968) induces apoptosis and alters both histone methylation and gene expression in cancer cells.