Glutaminase C-IN-1 (968) for cell activation

Catalog no.

B1198-25

Size

25 mg

Price

632 EUR

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Is this a salt?

No

Is it cell-permeable?

Yes

Peptide sequence

N/A

Supplied with

N/A

Tissue

cell

Storage condition

-20°C

Molecular weight

475.42

Shipping condition

gel pack

Maximum time for storage

36 months

CAS number

311795-38-7

Category

Biochemicals

Purification

≥98% by HPLC

Reconstitute instructions

DMSO (>5 mg/ml)

Physical appearance

Off-white solid

Molecular formula

C₂₇H₂₇BrN₂O

Storage instructions

Protect from air and light

Additional description

For cells, cell lines and tissues in culture till half confluency.

Other name

5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one

Description

Glutaminase C-IN-1 (968) a cell-permeable, reversible inhibitor of a mitochrondrial glutaminase splice variant, glutaminase C (IC₅₀ = ~2.5 µM), which is commonly found in cancer cells. Glutaminase C-IN-1 (968) blocks transformation induced by Rho GTPases and inhibits the proliferation of non-invasive epithelial (T-47D and MDA-MB-361) and invasive mesenchymal (MDA-MB-231 and Hs578T) cancer cells, without affecting normal cells. Glutaminase C-IN-1 (968) induces apoptosis and alters both histone methylation and gene expression in cancer cells.